Endocrine Abstracts

OBJECTIVE: To investigate the association between APD, treated Cushing's disease and severe hypopituitarism.METHODS: Fifty-seven patients (42 female), in remission after treatment for Cushing's disease, were studied. The cohort comprised 13 patients with, and 44 without APD. APD was defined as a serum prolactin persistently below the detection limit of the assay. Age and gender did not significantly differ between sub-groups.RESULT...

A 31 year old man with a 12 month history of uncontrolled hypertension was referred for further investigation. He complained of easy bruising, muscle weakness and severe back and hip pains. Clinical signs included cushingnoid facies, centripetal obesity, atrophic skin, peripheral oedema and BP of 150/104. Initial investigations confirmed Cushing's syndrome with 24 hour urinary free cortisol 696 nanomols per litre and 9am plasma cortisol 658 nanomols per litre following midnigh...